 | George Wittenberg,
M.D., Ph.D.
Associate Professor
Laboratory for Research on Arm Function and Therapy (RAFT)
Neurology, VA Baltimore GRECC
School of Medicine
410-706-4456 (BRB) or 410-605-7000 ext. 4128
GWittenb@GRECC.UMaryland.edu
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ResearchMy ongoing research interests presently lie in using transcranial magnetic stimulation (TMS) and functional imaging to understand motor cortical reorganization following stroke and in designing and testing new methods for neurorehabilitation. I moved to the University of Maryland from Wake Forest University in 2006, I have divided my work into 1. data analysis (from Wake Forest), 2. active-ongoing (spanning both institutions) , and 3. development-stage projects.
1. Data Analysis from Wake Forest.
a. Longitudinal TMS and fMRI of acute to subacute (5 days to 6 mo.) motor recovery after stroke
b. Longitudinal TMS and fMRI of rehabilitation-related subacute (4 mo. to 1 yr.) motor recovery after stroke
c. Cross-sectional fMRI study of dressing-related skills in younger and older normal subjects and
chronic stroke subjects
2. Active-ongoing
a. Motor maps in children with cerebral palsy: a study of the relationship between motor map geometry as determined by TMS and motor ability.
b. VA Cooperative study on robotic upper extremity rehabilitation in chronic stroke patients
3. Development stage
a. TMS and pilot fMRI study to investigate basis for robotic rehabilitation-related changes in motor function.
b. TMS effects on motor performance in the robotic rehabilitation environment
c. Adaptive control of multiple modalities in technology-assisted rehabilitation
Functional Activation and Deactivation related to buttoning and unbuttoning a shirt button - fMRI from 12 normal young adults |
Lab Techniquestranscranial magnetic stimulation
servo-assisted rehabilitation training (robotic rehabilitation)
functional magnetic resonance imaging
motor function assessment
PublicationsWittenberg GF, Bastings EP, Fowlkes A, Morgan TM, Good DC, Pons TP. Dynamic course of intracortical TMS paired-pulse responses during recovery of motor function after stroke. Neurorehabilitation and Neural Repair 2007 21:568-573.
Gerloff C, Bushara K, Sailer A, Wassermann EM, Chen R, Matsuoka T, Waldvogel D, Wittenberg GF, Ishii K, Cohen LG, Hallett M. Multimodal imaging of brain reorganization in motor areas of the contralesional hemisphere of well recovered patients after capsular stroke. Brain 2006; 129: 791-808.
Wittenberg GF, Werhahn KJ, Wassermann EM, Herscovitch P, Cohen LG. Functional connectivity between somatosenosry and visual cortex in early blind humans. Eur J Neurosci. 2004 Oct; 20(7):1923-1927.
Wittenberg GF, Chen R, Ishii K, Bushara KO, Eckloff S, Croarkin E, Taub E, Gerber LH, Hallett M, Cohen LG. Constraint-Induced therapy in stroke: magnetic-stimulation motor maps and cerebral activation. Neurorehabilitation and Neural Repair 2003; 17:111-119.
Ziemann U, Wittenberg GF, Cohen LG. Stimulation-Induced Within-Representation and Across-Representation Plasticity in Human Motor Cortex. Journal of Neuroscience 2002; 22: 5563-5571.
Wittenberg GF, Bastian AJ, Dromerick AW, Thach WT, Powers WJ. Mirror movements complicate cerebral activation changes during recovery from subcortical infarction. Neurorehabilitation and Neural Repair 2000; 14:213-221.
Lockery SR, Wittenberg G, Kristan WB Jr., Cottrell GW: Function of identified interneurons in the leech elucidated using neural networks trained by back-propagation. Nature 1989; 340: 468-471. Personal HistoryPreviously, I was Director of the Rehabilitation Program within the Department of Neurology at Wake Forest University in Winston-Salem, North Carolina. I obtained my doctorate degree in Biology at the University of California, San Diego, in 1991 and completed medical school in 1993 at the same university. I then had further clinical and research training at Washington University, St. Louis and the National Institutes of Health (NIH). Laboratory PersonnelLauren Jones-Lush, PhD, post-doctoral fellow Back to All Faculty |
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